Search Results for "SCID"



Severe Combined Immune Deficiency and Combined Immune Deficiency

Severe Combined Immune Deficiency (SCID, pronounced "skid") is a potentially fatal primary immunodeficiency in which there is combined absence of T-lymphocyte and B-lymphocyte function. There are at least 13 different genetic defects that can cause SCID. These defects lead to extreme susceptibility to very serious infections. This condition is generally considered to be the most serious of the primary immunodeficiencies. Fortunately, e…


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Newborn Screening

Severe Combined Immune Deficiency (SCID) leads to life-threatening infections unless the immune system can be restored through a bone marrow transplant, enzyme replacement or gene therapy. Infants with SCID who lack a family history have been diagnosed in the past only after developing serious infections. Early identification of SCID through screening of all newborns can make possible life-saving intervention before infections occur. Currently,…


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IDF SCID Initiative

The IDF SCID Initiative was established as a project dedicated to address the acute need for a program for Severe Combined Immune Deficiency (SCID) education, awareness,and diagnosis. SCID, a type of primary immunodeficiency disease, is commonly known as bubble boy disease. Affected infants lack T lymphocytes; the white blood cells that help resist infections due to a wide array of viruses, bacteria and fungi. Babies with SCID appear healthy at…


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IDF SCID Newborn Screening Campaign

On May 21, 2010, the Department of Health and Human Services (HHS) announced the addition of Severe Combined Immunodeficiency (SCID) – commonly known as bubble boy disease – to the recommended uniform screening. It is imperative that we sustain this momentum by establishing newborn screening programs in all 50 states. Background SCID is a primary immunodeficiency disease. Affected infants lack T lymphocytes, the white blood cells t…


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New states screening all newborns for SCID – Utah and Pennsylvania!

Beginning July 1, 2013 two new states will be added to the list of states currently screening for Severe Combined Immune Deficiency.  Pennsylvania’s Newborn Screening and Follow-up Technical Advisory Board recommended the addition of SCID to the mandated follow-up panel. With the approval of the Pennsylvania Department of Health, SCID will be added to the list of diseases for which follow-up services are required for newborn children with…


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Stem Cell and Gene Therapy

Hematopoietic stem cell transplantation (HSCT) represents the mainstay of treatment for several severe forms of primary immunodeficiency diseases. Progress in cell manipulation, donor selection, the use of chemotherapeutic agents, and prevention and management of transplant-related complications has resulted in significant improvement in survival and quality of life after HSCT. In some forms of severe primary immunodeficiency diseases, gene ther…


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TX Dept. of State Health Services will add SCID to Newborn Screening Panel

The Texas Department of State Health Services (DSHS) will add Severe Combined Immunodeficiency (SCID) to the state’s Newborn Screening Panel beginning December 1, 2012. The Immune Deficiency Foundation (IDF), the national patient organization for persons with primary immunodeficiency diseases, commends the state of Texas and the dedicated volunteers who have advocated for this cause. Screening for SCID increases the probability of early de…


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Inheritance

Many diseases have a genetic origin and are passed on in families. Most primary immunodeficiency diseases are inherited in one of three different ways: X-linked recessive, autosomal recessive or autosomal dominant. Family history and laboratory studies can be helpful in establishing the possible role of genes or chromosomes in a particular primary immunodeficiency disease and may be useful to identify a particular pattern of inheritance. Inherit…


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Newborn Screening Would Save Lives

A Routine Test Could Save Babies Born with ‘Bubble Boy Disease,’ Yet the State Repeatedly Fails to Budget for It http://www.baltimoresun.com/news/opinion/oped/bs-ed-newborn-screening-20140210,0,1970795.story By Marcia Boyle 12:36 p.m. EST, February 10, 2014 Maryland is justifiably proud of being a leader in many health care initiatives. Yet when it comes to adopting a simple policy that would save the lives of babies, Maryland policy…


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Hats Off to Secretary Sebelius!! And Now the Real Work Begins!!

We are thrilled that in record time, the Secretary of Health and Human Services, Kathleen Sebelius, announced that Severe Combined Immunodeficiency Disease (SCID) will be added to the 29 disorders on the core panel for universal screening of all newborns in the United States. This panel consists of disorders for which the Federal Department of Health and Human Services recommends each state provide for mandatory newborn screening.  In January, t…


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