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The Immune Deficiency Foundation (IDF) has been extremely successful in ensuring that all 50 states are now screening for Severe Combined Immunodeficiency (SCID). As technology emerges, there will be more newborn screening tests available for different types of primary immunodeficiency diseases (PI). Building on our previous success, IDF is prepared to advocate for another nationwide newborn screening campaign for other types of PI when such technology is feasible.