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Scientists Identify the Genetic Mutation Causing "XMEN" Disease

NIAID investigators have identified a genetic mutation that may account for X-linked magnesium deficiency with Epstein-Barr virus (EBV) infection and neoplasia, or XMEN, a rare primary immune deficiency disease (PIDD) characterized by very low numbers of circulating CD4 T cells and uncontrolled, persistent EBV infections. The identification of this particular disease also answers a decades-old question about the specific roles that magnesium has for normal cell functions. This finding is reported online in the July 27 issue of Nature.


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