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COVID-19 Update, June 18, 2020

Kathleen Sullivan, MD, PhD is the Chief of Allergy and Immunology at Children's Hospital of Philadelphia and a member of the IDF Physician Advisory Committee. She put together a video update focused on antibodies. This video sets out to answer three questions:

  • Are all antibodies good?
  • Why can’t we just make a vaccine - any vaccine - and get going?
  • Are antibodies after a vaccine the same as after natural infection?

Types of Antibodies 

  • IgG (IgG1 IgG2 IgG3 IgG4) neutralization, memory (Most vaccines induce an IgG response)
  • IgA mucous membranes
  • IgM high avidity, first responder
  • IgD mucous membranes, tolerance
  • IgE Helminth infections

What do we know about antibodies to SARS CoV2?

  • Convalescent plasma seems to work
  • Antibodies seem to peak at about 2-3 weeks after infection
  • Sicker patients make more antibodies
  • Antibodies decline over two years 

Patient Lifestage: