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Chronic Granulomatous Disease (CGD) is a genetic (inherited) disease in which the body’s cells that eat certain invaders (also called phagocytes) do not make superoxide, hydrogen peroxide, and other chemicals needed to kill certain bacteria and molds. As a result of this defect, individuals with CGD have severe infections from bacteria, molds, and other environmental pathogens that do not typically cause infections in healthy people. Individuals with CGD can also have difficulty with immune cells forming knots called granulomas, hence the name of the disease. Additionally, individuals with CGD can get excessive inflammation even when there is not an infection, and that inflammation can cause intestinal and urinary problems.