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Medications & Managing Exposures

Effective management of Chronic Granulomatous Disease (CGD) relies on lifelong antibacterial and antifungal prophylaxis and, in some cases, interferon gamma. Early diagnosis of infection and prompt, aggressive use of appropriate antibiotics is the best way to treat CGD infections.

HSCT and Gene Therapy

Individuals with CGD can be treated with hematopoeitic stem cell transplantation (HSCT), which, in those with CGD, essentially replaces the defective phagocytes with working ones. Additionally, replacement of only the defective gene, called gene therapy, is currently available in clinical trials for X-linked CGD.


The long-term outcome for individuals with CGD is highly dependent upon how much superoxide the phagocytes are able to make.