The quality of life and longevity for patients with Chronic Granulomatous Disease (CGD) has improved dramatically over the last 50 years with knowledge of the phagocytic cell abnormality and appreciation of the need for early, aggressive antibiotic therapy when infections occur.

The great majority of children with CGD can expect to live well into adulthood, and many adult patients with CGD have jobs, get married and have children. However, patients with CGD remain at significant risk for infection throughout life. They must take their prophylactic drugs, remain cautious, and be vigilant to seek early diagnosis and treatment for possible infections.

Hospitalizations may be required for individuals with CGD to locate sites and causes of infections. Intravenous antibiotics may be needed for serious infections. Prophylactic antibiotics and treatment with interferon gamma increase healthy periods. The vast majority of individuals reach adulthood, when serious infections tend to occur less frequently.