There are five different genetic kinds of CGD. The most common form in North America is called X-linked because the affected gene for part of the NADPH complex is on the X chromosome (70% of cases in the U.S.) and affects almost only males. The other types of CGD are due to autosomal recessive mutations where two abnormal copies of the gene for other parts of the NADPH complex lead to symptoms of CGD, therefore males and females are equally affected. In addition, girls carrying the X-linked gene may have autoimmune problems, like lupus of the skin, and sometimes may have serious infections. It is important to follow the neutrophil function in females carrying the abnormal x-linked gene, since this can change over time, and lead to increased risk of CGD symptoms including infections and IBD.