Chapter 3: Common Variable Immune Deficiency Phenotypes
Download this chapter from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition.
Chapter 2: Antibody Deficiency with Absent B Cells
Download this chapter from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition.
Chapter 1: The Immune System and Primary Immunodeficiency Diseases
Download this chapter from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition.
IDF Patient & Family Handbook for Primary Immunodeficiency
The sixth edition of IDF's handbook contains comprehensive information about the diagnosis, treatment, and management of primary immunodeficiencies.
Wiskott-Aldrich syndrome (WAS)
Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency (PI) that causes bleeding problems and eczema in addition to susceptibility to infections. It is inherited in an X-linked recessive manner.
WHIM syndrome
Warts, hypogammaglobulinemia, immunodeficiency, myelokathexis (WHIM) syndrome is an ultra-rare and difficult-to-diagnose primary immunodeficiency (PI) in which individuals are susceptible to life-threatening bacterial infections and to human papillomavirus (HPV) infections.
Transient hypogammaglobulinemia infancy
When it takes longer than expected for a baby to make their own IgG antibodies, they may have transient hypogammaglobulinemia of infancy (THI).
STAT1 and STAT3 gain of function
STAT1 and STAT3 gain of function are autosomal dominant primary immunodeficiencies with significant autoimmunity as a result of immune dysregulation.
Specific antibody deficiency
Individuals with specific antibody deficiency have normal levels of antibodies (immunoglobulins) but cannot produce antibodies to specific types of microorganisms that cause respiratory infections.
Selective IgM deficiency
Individuals with selective IgM deficiency have low levels or lack immunoglobulin M (IgM) but have normal levels of IgA, and IgG. These individuals may have no illness, whereas others develop a variety of illnesses, including infections, allergies, and autoimmunity.
