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Immunoglobulin (Ig) Replacement Therapy

Ig replacement therapy is both lifesaving and often lifelong, and is one of the most important and successful therapies for people with PI that affect antibody production.

Immunoglobulin Product Guide

IDF's downloadable booklet showing the characteristics of immunoglobulin products used to treat primary immunodeficiencies licensed for use in the United States.

Manufacturers & Assistance Programs

Learn more about the manufacturers who make products for people with PI, as well as reimbursement assistance programs on their websites.

Addressing the Ongoing Plasma / Ig Shortage

Since late 2018, the Immune Deficiency Foundation (IDF) has been tracking a troubling shortage of plasma-based immunoglobulin (Ig) products, which are lifesaving, lifelong treatments for people with primary immunodeficiencies (PI), specifically those who are antibody deficient. We continue to monitor the situation day-to-day and week-to-week and offer guidance and input where we can to make a difference.

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Clinical Trials

Clinical trials are necessary to develop safe and effective products with limited side effects while providing the most therapeutic benefit.

Gene Therapy

Gene therapy is an experimental treatment that has been used to treat people with severe forms of PI, who do not have a matched sibling donor.

Hematopoietic Stem Cell Transplantation

When PI is likely to cause significant harm or death to someone, Hematopoietic Stem Cell Transplantation (HSCT) may be the best treatment option.