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BCL10 deficiency

Related gene: BCL10

Inheritance pattern: Autosomal recessive

Deficiency of BCL10 is a rare combined immunodeficiency (CID) associated with severe recurrent infections and autoimmunity. This disorder results in decreased numbers of memory T cells and B cells, and the absence of regulatory T cells. The best treatment for this disorder is unclear, though Ig replacement therapy and preventative antibiotics are likely warranted, and hematopoietic stem cell transplantation (HSCT) should be considered given the severity of this disorder.

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Learn more about combined immune deficiencies.

This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.

Adapted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition 
Copyright ©2019 by Immune Deficiency Foundation, USA