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CD70 deficiency

Related gene: CD70

Inheritance pattern: Autosomal recessive

CD70 deficiency is a rare form of combined immunodeficiency with hypogammaglobulinemia and low CD8+ T cells. Individuals are particularly susceptible to chronic Epstein-Barr virus (EBV) and at high risk of EBV-associated lymphoma. Severe varicella (chickenpox) infections have also been described. Ig replacement therapy and prophylactic antibiotics are recommended in this disorder, and hematopoietic stem cell transplantation (HSCT) should also be strongly considered given the high risk of malignancies.

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Learn more about combined immune deficiencies.

This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.

Adapted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition 
Copyright ©2019 by Immune Deficiency Foundation, USA