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Coronin 1A deficiency

Related gene: CORO1A

Inheritance pattern: Autosomal recessive

Coronin 1A deficiency is associated with a very low number of T cells, with impaired function, similar to severe combined immunodeficiency (SCID). However, unlike in SCID, affected individuals have a functioning thymus. They can also produce antibodies, though they are non-specific and do not function well. They have severe, early predisposition to infections, as well as early lymphomas. Most have also had neurological complications, though this may be due to confounding factors. Hematopoietic stem cell therapy (HSCT) has been shown to improve the immunodeficiency aspect of the disease.

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Learn more about combined immune deficiencies.

This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.

Adapted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition 
Copyright ©2019 by Immune Deficiency Foundation, USA