Skip to main content
IDF logo

LICS syndrome

Related gene: NSMCE3

Inheritance pattern: Autosomal recessive

An autosomal recessive condition, a lack of this protein causes a type of DNA repair defect called lung disease, immunodeficiency, and chromosome breakage syndrome (LICS). Children with this condition have severe lung disease very early in life and are highly susceptible to viral pneumonia. Distinctive facial features have been reported. Immunoglobulin (Ig) replacement therapy may be indicated.

Read the latest research

Learn more about combined immune deficiencies.

This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.

Adapted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition 
Copyright ©2019 by Immune Deficiency Foundation, USA