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RelB deficiency

Related gene: RELB

Inheritance pattern: Autosomal recessive

RelB deficiency has been found in a small number of individuals with poor T cell and B cell function in spite of normal lymphocyte numbers. Recurrent bacterial infections have been described beginning in the first year of life. Rheumatoid arthritis was described in one child with RelB deficiency. Hematopoietic stem cell transplantation (HSCT) has successfully treated the immunodeficiency, but it is unclear if arthritis resolves after transplantation.

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Learn more about combined immune deficiencies.

This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.

Adapted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition 
Copyright ©2019 by Immune Deficiency Foundation, USA