Skip to main content
IDF logo

RIDDLE syndrome

Related gene: TNF168

Inheritance pattern: Autosomal recessive

RIDDLE is short for radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties.  It is an autosomal recessive disorder, in which individuals have difficulty repairing DNA damage sustained by the cells. Individuals can have recurrent sinopulmonary infections due to low production of immunoglobulin and may require immunoglobulin (Ig) replacement therapy. They also share a high risk of developing cancer during their lifetime.

Read the latest research

Learn more about combined immune deficiencies.

This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.

Adapted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition 
Copyright ©2019 by Immune Deficiency Foundation, USA