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X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN)

Gene: MAGT1

Inheritance pattern: X-linked

XMEN is seen in boys, and is characterized by CD4 T cell lymphopenia, chronic EBV infections, and lymphoproliferative disorders related to the EBV. All have decreased cytolytic function, and may have decreased antibody responses due to their low CD4 T cells. Oral magnesium supplementation has been proposed in the treatment of this condition, but it is not clear whether it is clinically helpful. Hematopoietic stem cell transplantation (HSCT) may be curative, though there is limited experience.

Learn more about combined immune deficiencies.

This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.

Adapted from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition 
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