Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Learn more about PI
Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Learn more about living with PI
Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Get involved today
Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
Learn more about research

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Immune Deficiency Foundation names new medical director

February 13, 2026

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Man with X-linked hyper IgM first-ever to receive novel gene therapy

February 11, 2026

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2025 Community impact report

February 09, 2026

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Kim Nichols

Associate Professor

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3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104-5127
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Why PI affects the skin: Common rashes, infections, and immune dysregulation (dermatology deep dive)

February 03, 2026

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PI diagnosis documentation key for prior authorizations

January 29, 2026

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Moderna

https://www.modernatx.com/en-US

2025 Research Grant Program awardees; from left to right, Drs. Eric Allenspach, Caroline Kuo, Ashley Lee, and Patrick O'Connell.

Grantees tackle rare PIs from basic biology to treatment

January 22, 2026

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Immune Deficiency Foundation
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Understanding PI

Living with PI

Get involved

Advancing research and clinical care

Immune Deficiency Foundation names new medical director

Man with X-linked hyper IgM first-ever to receive novel gene therapy

Want articles and podcasts in real time?

2025 Community impact report

Kim Nichols

Why PI affects the skin: Common rashes, infections, and immune dysregulation (dermatology deep dive)

PI diagnosis documentation key for prior authorizations

Moderna

Grantees tackle rare PIs from basic biology to treatment

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