You are not alone
Primary immunodeficiency (PI) doesn’t have to feel isolating.
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Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
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Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
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Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
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Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
We're here for you
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Get involved
Advocate
Even if you’re new to PI advocacy, there are many ways to raise awareness. We’ll help you get started.
Give
Our resources, services, and outreach are largely funded by donors like you.
Volunteer
Your gift of time makes a difference. IDF always needs peer support participants and event volunteers.
Fundraise
Whether you join the IDF Sustainers Club or start a Facebook fundraiser, all efforts can make a difference.
Watch IDF's new documentary
"Compromised: Life Without Immunity" takes you inside the rarely-seen world of primary immunodeficiency. Through six powerful stories, discover how strength, support, and medical care make life possible despite seemingly impossible challenges. Join us for an upcoming screening or host your own.
A combined impact: More than just fun and games
When two of the internet's most engaging content creators—CDawgVA (Connor Colquhoun) and VTuber Ironmouse—came together to support the Immune Deficiency Foundation, something extraordinary happened. What began as a friendship between a charismatic streamer and a talented VTuber living with common variable immune deficiency (CVID) has grown into one of the most impactful partnerships in content creator fundraising.
2025 Medical Summit
Join the Immune Deficiency Foundation October 8-9, 2025 to strengthen your clinical toolkit, network with leaders in the field of immunology, and connect the dots on primary immunodeficiency care.
This comprehensive 2-day event for clinicians is explicitly designed for immunology-adjacent healthcare professionals seeking to enhance their ability to serve patients with primary immunodeficiencies.
How well do you know your immune system?
Take our self-assessment to find out if your symptoms could point to a primary immunodeficiency (PI). It’s an informative way to gather insights that you can discuss with your healthcare provider.
Let us guide you.
If you are living with PI, think you might have PI, are a caregiver, a healthcare professional, or are just looking to learn more we can help.
Who is the Immune Deficiency Foundation?
IDF transforms the lives of tens of thousands each year*
1,310,185
website sessions linking the community to vital resources.
1,496
individuals turned to AskIDF to 1,910 PI-related questions.
30,694
individuals living with PI were supported and empowered.
*statistics based on 2024 Community Impact Report
Learn and share
Be a plasma hero
The more we learn about plasma, the more we realize its life-saving potential. We need heroes to step up, donate, and save lives.
Promote plasma donation
Types of PI
There are more than 450 primary immunodeficiencies, also known as inborn errors of immunity (IEI).
Explore PI types
Recursos en español
¡Bienvenidos! Para ver nuestros recursos disponibles, haga clic en el siguiente enlace.
Ver los recursos
IDF podcast
Listen to the latest episode of the IDF Podcast, or one of our sub-series Undiagnosed or Bold Conversations.
Listen or subscribe
Videos & recordings
Join IDF on YouTube to help spread awareness and education about PI and tune in to see what is happening.
Watch videos
Immunocompromised Collaborative
Joining forces to protect the most vulnerable against infectious disease.
Learn about the collaborative
Join an IDF event
Learn more about all the ways to learn, connect, and engage with IDF, whether online and in person.
Stay informed
Browse the latest news articles, videos, and podcasts to find the most up-to-date information about advancements in PI treatments, portrayal in the media, and other IDF efforts.
Sign up for updates from IDF
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