Compromised:
Life Without Immunity
A documentary from the Immune Deficiency Foundation.
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Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
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Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
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Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
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Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
Compromised:
About the film
"Compromised: Life Without Immunity" offers an intimate look into the world of those living with primary immunodeficiencies. This powerful documentary follows the inspiring journeys of individuals who face life-threatening challenges daily, yet refuse to let their conditions define them. From children to adults, patients and families share their struggles and triumphs, while medical experts provide insight into the fight against these rare diseases. Heartbreaking yet hopeful, this film reveals the extraordinary resilience of the human spirit and the urgent need for greater awareness and support in the medical community.
Stream the documentary
Watch "Compromised" now
Host a screening
Bring this important story to your community. Host a screening and spark conversations that matter.
Meet the cast
Victoria
Living with an unspecified primary immunodeficiency
Dionne
Living with common variable immune deficiency (CVID)
Jerry
Living with severe combined immunodeficiency (SCID)
Ben
Living with common variable immune deficiency (CVID)
Kim
Living with specific antibody deficiency (SAD)
Shane
Living with chronic granulomatous disease (CGD)
Start a conversation
Panel discussion
Meet the families who shared their stories for the documentary in this recorded panel discussion from the 2024 PI Conference.
Watch the recording
Film screening hosting tips
After registering to host a screening, view our hosting kit for the next steps and tips on hosting a successful screening.
View the hosting kit
Discussion guide
Read our discussion guide before your screening. Get insights from the director, talking points to lead guided discussions, and more.
See the guide
Find a Compromised: Life Without Immunity screening near you.
2025 Screenings (in person)
October 25 | Los Angeles
Awareness Film Fest
September 9 | Philadelphia
Cinehealth Film Festival
May 1 | Washington DC
Congressional screening
2025 Screenings (online)
April 25 | Virtual
World PI Week special screening
March 14 | Virtual
PI (pi) Day special screening
February 28 | Virtual
Rare Disease Day special screening
January 31 | Virtual
International Zebra Day special screening
2024 Special events
November 17 | St. Louis, MO
Hosted by Rare & Black/Washington University
October 10 | Houston, TX
Hosted by Texas Children's Hospital
September 7 | New York, NY
Selection of Social Impact Film Festival
June 21 | Chicago, IL
Special presentation at PI Conference
Curious about PI?
Know your immune system
Find out if your symptoms could point to a primary immunodeficiency (PI). Gather insights to discuss with your healthcare provider.
Take self-assessment
Understand PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI.
Learn more
Get support
Has your life been impacted by PI? When navigating symptoms, diagnosis, treatment, insurance, and emotions, turn to IDF for answers and connections.
Get support
Browse resources
If you think you might have PI, or are just looking to learn more, we can help. Browse through these resources to better understand PI.
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