The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
Vaccines are one of the most significant public health achievements of the 20th century, revolutionizing disease prevention and dramatically improving the health and well-being of the American people. This success was driven by strong support and trust in established vaccine science, championed by public servants and healthcare leaders. Vaccine uptake depends on widespread public education, vaccine promotion, and robust support for the administration and distribution of vaccines. The public relies on national health leaders for guidance and recommendations, and the Immune Deficiency Foundation is committed to working together to uphold this legacy.
People who are immunocompromised, including those with primary immunodeficiencies (PI), rely on community immunity to minimize their exposure to dangerous germs. Community immunity describes the level of immunity, gained either through widespread vaccination or natural infection, needed within a group of people to prevent an infectious disease from spreading. A decrease in vaccination rates weakens community immunity, putting those who are most vulnerable at higher risk of severe, preventable infections.
Seventy-two million Americans, or 1 in 5 individuals, are at risk when not enough people get immunized, including:
In addition, children who are too young to be fully vaccinated are at risk as well. A family member, friend, or neighbor could be the person who gets severely ill or dies from a vaccine-preventable disease during an outbreak.
The foundation’s advocacy focuses on strongly supporting the immunocompromised community and the science that has proven to be effective in protecting them. IDF is the founding member of the Immunocompromised Collaborative, the united voice of communities whose health status makes them most vulnerable to threats from infectious disease. These communities include individuals with PI, blood cancers like leukemia and lymphoma, autoimmune conditions, HIV/AIDS, and organ or bone marrow transplants.
The immunocompromised community faces new challenges from federal health officials who have harmed access, consumer confidence, and decision-making related to vaccines. IDF advocates directly with the U.S. Food and Drug Administration (FDA), the U.S. Centers for Disease Control and Prevention (CDC), and Congress to ensure that policymakers understand the life-threatening consequences for Americans who are immunocompromised if rates of infectious disease increase because fewer people choose to be vaccinated.
When policymakers need to hear the PI community’s perspective, you will receive an Action Alert by email. Customize each alert with your information and hit send. It's that easy.
The foundation is advocating against legislation that would reduce vaccine access and remove existing public health protections. The organization:
This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice. Additionally, links to other resources and websites are shared for informational purposes only and should not be considered an endorsement by the Immune Deficiency Foundation.
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The Immune Deficiency Foundation improves the diagnosis, treatment, and quality of life for every person affected by primary immunodeficiency.
We foster a community that is connected, engaged, and empowered through advocacy, education, and research.
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