Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Learn more about PI
Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Learn more about living with PI
Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Get involved today
Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
View resource details

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Whether you are someone living with PI, a caregiver, or a healthcare professional, you’ll find articles, videos, podcasts, and more to help deepen your understanding of PI.

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Taylor Kane feeds her father John Kane, diagnosed with adrenoleukodystrophy (ALD), which affected his physical and cognitive functioning.

Remember The Girls empowers women affected by X-linked conditions

March 30, 2023

Read article

Undiagnosed episode 1: "The caretaker"

March 06, 2023

Listen to podcast

CVID diagnosis sheds light on a lifetime of infections

February 09, 2023

Read article

Son with chronic granulomatous disease goes through BMT with family’s support

January 25, 2023

Read article

Susan Day is surrounded by her family, from left, son Jackson, husband Jason, and son Jace.

Mom’s common variable immune deficiency diagnosis explains lifelong infections and fatigue

January 09, 2023

Read article

New campaign offers important personal perspective for the immunocompromised community and COVID-19

December 19, 2022

Read article

Family navigates toddler’s chronic granulomatous disease

November 29, 2022

Read article

IDF Peer Support volunteers provide encouragement and assistance

November 14, 2022

Read article

Journal chronicles bone marrow transplant for CGD

September 29, 2022

Read article

XLA Life supports community with content, webinars, research

September 27, 2022

Read article

Family coping with chronic granulomatous disease relies on tight bonds

August 31, 2022

Read article

Donor spotlight: Nupur Murthy

July 21, 2022

Read article

Evangelina, born with ADA-SCID, thrives after gene therapy

July 15, 2022

Read article

SCID Summit: A parent's journey with ZAP70 deficiency

July 06, 2022

Watch video

Donor spotlight: London

June 23, 2022

Read article

Cindy Kisik, adult with ADA-SCID, advocates for mental health awareness

June 13, 2022

Read article

Donor spotlight: Reverend, Freddye James, D.MIN.

May 27, 2022

Read article

SCID advocate devotes herself to helping parents navigate medical world

May 13, 2022

Read article

What is PI?

Learn the signs and symptoms of PI and when it might be time to ask your doctor about it.

Learn about PI

Get support

IDF coordinates support groups, events, and one-on-one connections, so you never need to feel alone.

See all support groups

Ask IDF

Getting answers can help create peace of mind. Ask us anything and we'll consult with experts.

Submit a question

I'm moving and need a new doctor. How do I find a specialist near me?

Specialists can be located online through the IDF Clinician Finder. (Please note, if no results populate, increase the distance from your address. You can also search by your state).

Please note the following important information about the list of specialists:

These clinicians have voluntarily reported to IDF that they diagnose, treat, and manage patients with primary immunodeficiency (PI). Please know that IDF does not verify these reports.
This is not a referral. IDF does not recommend one clinician or medical facility over another or refer patients to a particular provider.
It is your responsibility or that of your legal guardian to evaluate, select and engage a clinician or facility, given your insurance coverage and other circumstances, to help you manage your PI.
There might be other clinicians at each facility that also treat PI.

Questions to ask while evaluating a clinician or facility:

Do you accept my insurance?
Do you diagnose and treat patients with primary immunodeficiency diseases? (If already diagnosed, name the PI.)
How many patients with primary immunodeficiencies are treated at your facility?

For those receiving Ig replacement therapy:

Do you prescribe IVIG and SCIG?
Do you prescribe more than one brand of immunoglobulin?
Do you offer patients receiving IVIG the option of receiving their infusion in a medical or home setting?

Some patients also find physicians through our Get Connected Groups or IDF Friends.

I missed your education event. Can I still access the information?

Our virtual education programs are recorded and uploaded to our website resource library and YouTube page. You can view our webinars only via our YouTube webinars playlist.

Immune Deficiency Foundation
7550 Teague Road, Suite 220
Hanover, Maryland 21076

P: 410-321-6647

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Understanding PI

Living with PI

Get involved

Advancing research and clinical care

Browse resources

Remember The Girls empowers women affected by X-linked conditions

Undiagnosed episode 1: "The caretaker"

CVID diagnosis sheds light on a lifetime of infections

Son with chronic granulomatous disease goes through BMT with family’s support

Mom’s common variable immune deficiency diagnosis explains lifelong infections and fatigue

New campaign offers important personal perspective for the immunocompromised community and COVID-19

Family navigates toddler’s chronic granulomatous disease

IDF Peer Support volunteers provide encouragement and assistance

Journal chronicles bone marrow transplant for CGD

XLA Life supports community with content, webinars, research

Family coping with chronic granulomatous disease relies on tight bonds

Donor spotlight: Nupur Murthy

Evangelina, born with ADA-SCID, thrives after gene therapy

SCID Summit: A parent's journey with ZAP70 deficiency

Donor spotlight: London

Cindy Kisik, adult with ADA-SCID, advocates for mental health awareness

Donor spotlight: Reverend, Freddye James, D.MIN.

SCID advocate devotes herself to helping parents navigate medical world

What is PI?

Get support

Ask IDF

I'm moving and need a new doctor. How do I find a specialist near me?

Please note the following important information about the list of specialists:

Questions to ask while evaluating a clinician or facility:

For those receiving Ig replacement therapy:

I missed your education event. Can I still access the information?

Sign up for updates from IDF