| Immune Deficiency Foundation

Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Learn more about PI
Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Learn more about living with PI
Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Get involved today
Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
View resource details

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IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition

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Chapter 1: The Immune System and Primary Immunodeficiency Diseases

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Chapter 2: Antibody Deficiency with Absent B cells

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Chapter 3: Common Variable Immune Deficiency Phenotypes

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Chapter 4: Selective Immunoglobulin Deficiency: IgA and IgM

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Chapter 5: Hyper IgM Syndromes

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Chapter 6: IgG Subclass Deficiency and Specific Antibody Deficiency

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Chapter 7: Transient Hypogammaglobulinemia of Infancy

Immune Deficiency Foundation
7550 Teague Road, Suite 220
Hanover, Maryland 21076

P: 410-321-6647