| Immune Deficiency Foundation

Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Learn more about PI
Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Learn more about living with PI
Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Get involved today
Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
View resource details

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Moderna

https://www.modernatx.com/en-US

2025 Research Grant Program awardees; from left to right, Drs. Eric Allenspach, Caroline Kuo, Ashley Lee, and Patrick O'Connell.

Grantees tackle rare PIs from basic biology to treatment

January 22, 2026

Thumbnail for the webinar "Decoding PI: Dermatological issues in PI"

Decoding PI: Dermatological issues in PI

January 21, 2026

Irene Chen with cells

Pharmacist with CVID receives bone marrow transplant

January 15, 2026

Primary immunodeficiency & dental health: Protecting your mouth when your immune system is fragile

January 13, 2026

Listen to podcast

Child receiving vaccine

Foundation provides guidance amid changing vaccine recommendations

January 13, 2026

Cover of report on 2024 National Immunoglobulin Treatment Survey.

2024 National Immunoglobulin Treatment Survey report

January 12, 2026

Teacher and student 2

Education policy changes could impact students with PI

January 07, 2026

Primary immunodeficiency & oral health: Why PI causes gum disease, ulcers, and infections

December 17, 2025

Undiagnosed podcast thumbnail with person walking in shadow toward light. Text in corner reading "Stories of the long journey to PI diagnosis".

Undiagnosed: Reuben & Sherri Johnson on CGD, chronic illness, and the fight for healthcare

December 17, 2025

Listen to podcast

Immune Deficiency Foundation
7550 Teague Road, Suite 220
Hanover, Maryland 21076

P: 410-321-6647