| Immune Deficiency Foundation

Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Learn more about PI
Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Learn more about living with PI
Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Get involved today
Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
View resource details

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Nurse vaccinating girl

Update: ACIP meeting adds to COVID-19 vaccine confusion

September 24, 2025

thumbnail for the ChronicXTwenties podcast which features three circles of Immune Deficiency Foundation colors, and the text "young adulthood, rare disease, and the joy you deserve".

ChronicXTwenties: College and mental health roundtable

September 22, 2025

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Thumbnail for selective IgA and IgM deficiencies webinar

Lunch and Learn: Selective IgA and IgM deficiencies

September 19, 2025

Jennifer Harry stands in front of the Capitol

Mother with specific antibody deficiency advocates for vaccines

September 11, 2025

Two pairs of hands in an embrace with text which reads "Living well with PI: Caregiving for chronic illness"

Living well with PI: Caregiving for chronic illness

September 08, 2025

Person typing on a computer

New awareness campaign from Quest Diagnostics

September 05, 2025

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Woman on the computer

Immune system self-assessment supports patients seeking a diagnosis

August 26, 2025

Foundation Focus | August 2025

August 25, 2025

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Lunch and Learn: HLH with Dr. Michael Jordan

August 21, 2025

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Undiagnosed podcast thumbnail with person walking in shadow toward light. Text in corner reading "Stories of the long journey to PI diagnosis".

Undiagnosed: The wounds that won't close

August 19, 2025

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Immune Deficiency Foundation
7550 Teague Road, Suite 220
Hanover, Maryland 21076

P: 410-321-6647