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Cover of the Patient & Family Handbook for Primary Immunodeficiency, Seventh Edition Preview.

Patient & Family Handbook for Primary Immunodeficiency, Seventh Edition Preview

June 22, 2026

The Patient & Family Handbook for Primary Immunodeficiency, Seventh Edition Preview, contains information about primary immunodeficiencies (PIs; also known as inborn errors of immunity), including symptoms, how they are diagnosed, treatments, and everyday life. 

Note that this preview edition contains the following chapters updated from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition. Additional chapters will be released as part of the final seventh edition.

Table of contents

Understanding PI

  • Chapter 1: Primary immunodeficiency and your immune system.
  • Chapter 2: Genetics.

Diagnosis

  • Chapter 3: Laboratory testing.
  • Chapter 4: Genetic testing.
  • Chapter 5: Newborn screening.

Treatment

  • Chapter 6: Preventative antibiotics and other antimicrobials.
  • Chapter 7: Immunoglobulin replacement therapy.
  • Chapter 8: Hematopoietic stem cell transplantation.
  • Chapter 9: Gene therapy.

Living with PI

  • Chapter 10: Nurturing physical and mental health.
  • Chapter 11: Vaccines.
  • Chapter 12: Navigating health insurance.
  • Chapter 13: Thriving in the workplace.
  • Chapter 14: Respiratory health.
  • Chapter 15: Digestive and liver health.
  • Chapter 16: Other body systems.
  • Chapter 17: Fertility and pregnancy.
  • Chapter 18: Caring for children and adolescents.
  • Chapter 19: Senior adults.
  • Chapter 20: Participating in clinical research.

Appendix: Medical specialties cheat sheet

Glossary

References

Copyright © 2026, Immune Deficiency Foundation, USA.

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This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice. Additionally, links to other resources and websites are shared for informational purposes only and should not be considered an endorsement by the Immune Deficiency Foundation.