The Patient & Family Handbook for Primary Immunodeficiency, Seventh Edition Preview, contains information about primary immunodeficiencies (PIs; also known as inborn errors of immunity), including symptoms, how they are diagnosed, treatments, and everyday life.
Note that this preview edition contains the following chapters updated from the IDF Patient & Family Handbook for Primary Immunodeficiency Diseases, Sixth Edition. Additional chapters will be released as part of the final seventh edition.
Table of contents
Understanding PI
- Chapter 1: Primary immunodeficiency and your immune system.
- Chapter 2: Genetics.
Diagnosis
- Chapter 3: Laboratory testing.
- Chapter 4: Genetic testing.
- Chapter 5: Newborn screening.
Treatment
- Chapter 6: Preventative antibiotics and other antimicrobials.
- Chapter 7: Immunoglobulin replacement therapy.
- Chapter 8: Hematopoietic stem cell transplantation.
- Chapter 9: Gene therapy.
Living with PI
- Chapter 10: Nurturing physical and mental health.
- Chapter 11: Vaccines.
- Chapter 12: Navigating health insurance.
- Chapter 13: Thriving in the workplace.
- Chapter 14: Respiratory health.
- Chapter 15: Digestive and liver health.
- Chapter 16: Other body systems.
- Chapter 17: Fertility and pregnancy.
- Chapter 18: Caring for children and adolescents.
- Chapter 19: Senior adults.
- Chapter 20: Participating in clinical research.
Appendix: Medical specialties cheat sheet
Glossary
References
Copyright © 2026, Immune Deficiency Foundation, USA.
Readers may redistribute this guide to other individuals for non-commercial use, provided the text, HTML code, and this notice remain intact and unaltered in any way. The Patient & Family Handbook for Primary Immunodeficiency, seventh edition preview© may not be resold, reprinted, or redistributed for compensation of any kind without prior written permission from the Immune Deficiency Foundation.

