Types of PI
There are more than 450 primary immunodeficiencies. Explore the definitions and symptoms of some of the most common types.
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Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
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Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
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Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
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Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
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TCRa deficiency
TCRa deficiency causes susceptibility to recurrent respiratory tract infections, candidiasis, gastroenteritis, and herpesvirus infections, as well as autoimmune symptoms.
TFR1 deficiency
Deficiency of transferrin receptor 1 (TFR1) is a rare, recessive immunodeficiency that causes hypogammaglobulinemia, defective T cell function, intermittent neutropenia and thrombocytopenia, and mild anemia.
Transcobalamin II deficiency
Transcobalamin II deficiency is a rare autosomal recessive type of primary immunodeficiency.
Transient hypogammaglobulinemia infancy
When it takes longer than expected for a baby to make their own IgG antibodies, they may have transient hypogammaglobulinemia of infancy (THI).
Tricho-hepato-enteric syndrome
Tricho-hepato-enteric syndrome (THES) is a rare, recessive disorder characterized by chronic diarrhea with poor growth, liver disease, hair and facial abnormalities, and immunodeficiency with impaired antibody function and lymphopenia.
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