Types of PI
There are more than 450 primary immunodeficiencies. Explore the definitions and symptoms of some of the most common types.
HLH occurs when histiocytes and lymphocytes become overactive and attack the body rather than just microorganisms.
This syndrome is a severe form of dyskeratosis congenita with poor growth inside the womb, microcephaly (small head), and pancytopenia (low numbers of all blood cells).
Hyper IgE syndromes (HIES) are rare forms of primary immunodeficiencies (PI) characterized by recurrent eczema, skin abscesses, lung infections, eosinophilia (high numbers of eosinophils in the blood), and high serum levels of immunoglobulin E (IgE).
Hyper IgM syndromes (HIGM) are characterized by decreased levels of immunoglobulin G (IgG) in the blood and normal or elevated levels of immunoglobulin M (IgM).
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