While fever is considered a sign of infection, many individuals PI anecdotally report a lower-than-normal average body temperature.
In 2018, the Immune Deficiency Foundation (IDF) conducted a non-clinical study of "Body Temperature in Patients with Primary Immunodeficiency," also referred to as "The Fever Study." The idea for this study arose from individuals with primary immunodeficiency (PI) who were a part of the IDF Friends online community, and the IDF PI CONNECT Research Forum. While fever is considered a sign of infection, on these websites, many patients with PI stated they had a diminished fever response when they were sick (i.e., they had temperatures lower than 101°F when they were experiencing an infection).
Misdiagnosing patients with PI who do not present the typical fever response can increase the likelihood of patients not receiving critical antibiotics needed to fight off an infection.
In response to that concern, IDF collaborated with Dr. Art Jongco and Dr. Kathleen Sullivan, and over 250 households were recruited to participate in the Fever Study.
For this study, both an adult with PI and an adult without PI who lived in the same household had to participate. Both were asked to record their temperatures three times a day for five consecutive days (between March 26, 2018 and March 30, 2018). They were sent a thermometer and observation booklet to fill out. At the end of five days, the participating households mailed their booklets back to IDF and were later compensated for their participation. Data from the study was analyzed by Dr. Shouling Zhang.
Click the image below to see the poster created from the study results.
Please contact us at firstname.lastname@example.org for more information on the fever study, or with additional questions about body temperature in patients with PI.
Join us at the Sheraton Grand Chicago Riverwalk in Chicago, IL, from June 20-22! The conference offers three days of connection, learning, and networking and features up-to-date information from world-renowned healthcare professionals and life management experts.
Travel scholarships are available! Apply by January 5, 2024.Register and apply
This page contains general medical and/or legal information that cannot be applied safely to any individual case. Medical and/or legal knowledge and practice can change rapidly. Therefore, this page should not be used as a substitute for professional medical and/or legal advice.
Receive news and helpful resources to your cell phone or inbox. You can change or cancel your subscription at any time.