| Immune Deficiency Foundation

Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
Learn more about PI
Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
Learn more about living with PI
Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
Get involved today
Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
View resource details

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Primary immunodeficiency & oral health: Why PI causes gum disease, ulcers, and infections

December 17, 2025

Undiagnosed podcast thumbnail with person walking in shadow toward light. Text in corner reading "Stories of the long journey to PI diagnosis".

Undiagnosed: Reuben & Sherri Johnson on CGD, chronic illness, and the fight for healthcare

December 17, 2025

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Heather Smith championed SCID families

December 16, 2025

Researchers looking in microscope

FDA approves first gene therapy for Wiskott-Aldrich syndrome

December 15, 2025

Vaccine

Foundation to follow medical societies' vaccine schedules in light of ACIP hepatitis B decision

December 09, 2025

Hayden Scott as a adult standing in a radiation machine.

PhD student with PI works to improve cancer care

December 04, 2025

Image reading "Lunch and learn: Primary immune regulatory disorders".

What are primary immune regulatory disorders (PIRD)? Symptoms, diagnosis, and treatment explained

December 03, 2025

Lamar

https://lamar.com

Dr. Michael Blaese with Ashanti DeSilva and Cindy Kisik at the 2013 IDF Conference.

The foundation's early years: Dr. Michael Blaese

December 02, 2025

Cancer risk in primary immunodeficiency (PI): Lymphoma, screening, and treatment explained

December 02, 2025

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Immune Deficiency Foundation
7550 Teague Road, Suite 220
Hanover, Maryland 21076

P: 410-321-6647